Journal article
Genetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses
A Moore, E Kane, LR Teras, MJ Machiela, J Arias, OA Panagiotou, A Monnereau, NW Doo, Z Wang, SL Slager, RCH Vermeulen, CM Vajdic, KE Smedby, JJ Spinelli, J Vijai, GG Giles, BK Link, AA Arslan, A Nieters, PM Bracci Show all
International Journal of Cancer | Published : 2026
DOI: 10.1002/ijc.70039
Abstract
Obesity has been associated with non-Hodgkin lymphoma (NHL), but the evidence is inconclusive. We examined the association between genetically determined adiposity and four common NHL subtypes: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, chronic lymphocytic leukemia, and marginal zone lymphoma, using eight genome-wide association studies of European ancestry (N = 10,629 cases, 9505 controls) and constructing polygenic scores for body mass index (BMI), waist-to-hip ratio (WHR), and waist-to-hip ratio adjusted for BMI (WHRadjBMI). Higher genetically determined BMI was associated with an increased risk of DLBCL [odds ratio (OR) per standard deviation (SD) = 1.18, 95% confidence ..
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